基本情况

    李文豪，男，1989年6月生，籍贯河南开封，博士，水产种质与育种系讲师，上海市教委“水产种质资源挖掘和良种创制战略创新团队”成员。2017年7月-2019年8月于新葡萄8883官网AMG水产养殖学博士后流动站进行博士后研究。2019年入职新葡萄8883官网AMG。主要承担《水产生物统计学》、《分子生物学》、《基因工程》等课程的教学工作。主持上海市，国家实验室开放基金等各类科研项目。先后获得海洋科学技术奖一等奖（极地鱼类适应性进化机制研究）、新葡萄8883官网AMG科技成果奖（自然科学类）三等奖（斑马鱼细胞低温适应的表观遗传调控机制研究）。2021年入选江苏省双创团队。发表论文20余篇, 主要论文以第一/通讯作者(含共同)发表在BMC biology (2), GigaScience, The FEBS Journal, Frontiers in Cell and Developmental Biology, Frontiers in Marine Science, Molecular Biomedicine, Aquaculture and Fisheries等杂志上。Frontiers in Ecology and Evolution等国内外期刊审稿人。

教育背景

2012.09--2017.06，新葡萄8883官网AMG理学博士（专业：生物学; 硕博连读）

2008.09--2012.06，河南师范大学农学学士（专业：水产养殖）

主要研究内容

利用南极及深渊生物资源，解析水生动物适应逆境的分子机制。通过解析南极鱼亚目鱼类的全基因组数据，利用比较基因组学, 群体遗传学的方法，构建鱼类耐受低温的调控网络，发掘在鱼类中提高低温耐受能力的重要基因，并通过分子操作验证其耐低温能力。从演化生物学的角度出发，为经济鱼类的耐低温育种、生长性状育种提供分子靶标。

主要研究方向

1.鱼类耐低温的分子机制与耐低温新品种育种的遗传基础

2.鱼类比较基因组学及演化生物学 (南极、深渊方向)

3.低温下鱼类性腺发育研究

主持和参与的科教项目

[1] 青岛海洋科学与技术试点国家实验室海洋生物学与生物技术功能实验室，开放基金，2020-01至2022-12，主持，已结题

[2] 新葡萄8883官网AMG，科技发展专项基金，2020-01至2021-12，主持，已结题

[3] 上海市人力资源和社会保障局，上海市博士后研究人员日常经费，2017-07至2019-08，主持，已结题

[4] 国家自然科学基金委，国家重点研发计划项目，2018YFD0900600，2018-01至2022-12，参与，已结题

[5] 国家自然科学基金委，国际合作项目，41761134050，2017-01至2019-12，参与，已结题

[6] 国家自然科学基金委，面上项目，31572611，2016-01至2019-12，参与，已结题

发表的主要论文情况

[1] Wenhao Li#, Mengdi Bu#, Ruiqin Hu, Shouwen Jiang, Liangbiao Chen* and George N. Somero*. Tissue-specific temperature dependence of RNA editing levels in zebrafish. BMC Biology, 2023, 21(1), 262.

[2] Ying Lu#, Wenhao Li#, Yalin Li#, Wanying Zhai#, Xuming Zhou#, Zhichao Wu, Shouwen Jiang, Taigang Liu, Huamin Wang, Ruiqin Hu, Yan Zhou, Jun Zou, Peng Hu, Guijun Guan, Qianghua Xu*, Adelino V.M. Canário*, Liangbiao Chen*. Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic Notothenioids. BMC biology, 2022, 20(1), 231.

[3] Liangbiao Chen#, Ying Lu#, Wenhao Li#, Yandong Ren, Mengchao Yu, Shouwen Jiang, Yanxia Fu, Jian Wang, Sihua Peng, Kevin T. Bilyk, Katherine R. Murphy, Xuan Zhuang, Mathias Hune, Wanying Zhai, Wen Wang, Qianghua Xu*, Chi-Hing Christina Cheng*. GigaScience, 2019, 8(4), giz016.

[4] Wenhao Li, Faxiang Wang, Shouwen Jiang, Binbin Pan, Qi Liu, Qianghua Xu*. Morphological and molecular evolution of hadal amphipod’s eggs provides insights into embryogenesis under high hydrostatic pressure. Frontiers in Cell and Developmental Biology, 2022, 10:987409. 

[5] Wenhao Li#, Faxiang Wang#, Shouwen Jiang, Binbin Pan, Jiulin Chan, Qianghua Xu*. The Adaptive Evolution and Gigantism Mechanisms of the Hadal “Supergiant” Amphipod Alicella gigantea. Frontiers in Marine Science, 2021, 8:743663.

[6] Xi Li#, Xinwen Li#, Wenhao Li#, Yingqing Zhang, Haiyan Guo, Guangxing Wang, Yayuan Li, Xiaowen Wu, Ruiqin Hu, Siyu Wang, Xiaomiao Zhao, Liangbiao Chen*, Guijun Guan*. Sex-specific meiosis response to Gsdf in medaka (Oryzias latipes). The FEBS Journal, 2023, 290(10): 2760-2779.

[7] Xin Zhang, Zhichao Wu, Mengdi Bu, Ruiqin Hu, Xiaowen Zhang, Wenhao Li*, Liangbiao Chen*. The CCAAT/Enhancer Binding Protein Beta (cebpb) is essential for the development of enveloping layer (EVL) in zebrafish. Aquaculture and Fisheries, 2023, 8(3): 252-260.

[8] Bingshe Han#, Wenhao Li#, Zuozhou Chen#, Qiongqiong Xu, Juntao Luo, Yingdi Shi, Xiaoxia Li, Xiaonan Yan, Junfang Zhang*. Variation of DNA methylome of zebrafish cells under cold pressure. PloS one, 2016, 11(8), e0160358.

[9] Hongying Hao#, Baolu Shi#, Jiacheng Zhang#, Ao Dai#, Wenhao Li#, Haidi Chen, Wenya Ji, Chenjia Gong, Chang Zhang, Jing Li, Li Chen, Bin Yao, Peng Hu, Hao Yang, Juergen Brosius, Shanshan Lai*, Qinghua Shi*, Cheng Deng*. The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding. Mol Biomed, 2022, 3(1): 1-18.

[10] Lang Gui#, Wenjie Lu#, Mijuan Shi#, Ruiqin Hu, Yan zhou, Yubang Shen, Xiaoyan Xu, Jie Liu, Huimin Xia, Yaping Wang, Wenhao Li*, Ying Lu*. Liver DNA methylation and transcriptome between 1-and 3-year-old grass carp. Aquaculture and Fisheries. 2020.

[11]Qianqian Yan, Wenhao Li, Xiaoting Gong, Ruiqin Hu, Liangbiao Chen*. Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated gluk2 Knockout in Zebrafish. Genes, 2022, 13(8): 1441.

[12]Ruiqin Hu, Yanna Xu, Bingshe Han, Yi Chen, Wenhao Li, Guijun Guan, Peng Hu, Yan Zhou, Qianghua Xu, Liangbiao Chen*. MiR-202-3p determines embryo viability during mid-blastula transition. Frontiers in cell and developmental biology, 2022: 1593.

[13] Lingyue Zhu, Daoqiang Geng, Bingbing Pan, Wenhao Li, Shouwen Jiang, Qianghua Xu*. Trace Elemental Analysis of the Exoskeleton, Leg Muscle, and Gut of Three Hadal Amphipods. Biological Trace Element Research, 2022, 200(3), 1395-1407.

[14]Qi Liu, Shouwen Jiang, Wenhao Li, Binbin Pan, Qianghua Xu*. Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods. Journal of Marine Science and Engineering, 2022,10(4), 454.

[15]Tao Zhou#, Lang Gui#, Mingli Liu, Wenhao Li, PengHu, Daniel F.C. Duarte, HongboNiu, Liangbiao Chen*. Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus. Fish & shellfish immunology, 2019, 84, 1145-1156.

[16]Jian Wang#, Yimeng Liu#, Shouwen Jiang, Wenhao Li, Lang Gui, Tao Zhou, Wanying Zhai, Zixuan Lin, Jiaying Lu, Liangbiao Chen*. Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture, 2019, 508, 167-177.

[17]Shue Chen, Mengchao Yu, Xu Chu, Wenhao Li, Xiujuan Yin, Liangbiao Chen*. Cold-induced retrotransposition of fish LINEs. Journal of Genetics and Genomics, 2017, 44(8), 385-394.

[18]Shaojun Huang, Ruonan Jia, Ruiqin Hu, Wanying Zhai, Shouwen Jiang, Wenhao Li, Faxiang Wang, Qianghua Xu*. Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps. Journal of Fish Biology, 2021, 99(6), 1998-2007.

[19]Yan Zhou#, Yanjie Zhang#, Shang Wei, Wei Li, Wenhao Li, Zhichao Wu, Shouwen Jiang, Ying Lu, Qianghua Xu, Liangbiao Chen*. Reduced Hypoxia Tolerance and Altered Gill Morphology at Elevated Temperatures May Limit the Survival of Tilapia (GIFT, Oreochromis niloticus) under Global Warming. Fishes, 2022,7(5), 216.

[20] Ruonan Jia, Shaojun Huang, Wanying Zhai, Shouwen Jiang, Wenhao Li, Faxiang Wang, Qianghua Xu*. Comparative proteomic analysis of head kidney among three Antarctic fishes. Marine Biology, 2022,169(5), 1-11.

[21]Shihao Wang, Huarong Huang, Haiying Xiang, Bin Gu, Wenhao Li, Liangbiao Chen*, Ming Zhang*. Wnt Signaling Modulates Routes of Retinoic Acid-Induced Differentiation of Embryonic Stem Cells. Stem Cells and Development, 2019,28(19), 1334-1345.

[22]Mingli Liu, Ruiqin Hu, Wenhao Li, Wenyi Yang, Qianghua Xu, Liangbiao Chen*. Identification of Antibacterial Activity of Hepcidin From Antarctic Notothenioid Fish. Frontiers in Microbiology, 2022, 13:834477.

[23]李文豪,冉皓宇,陈良标.低温胁迫导致斑马鱼尾部发育畸形的分子机制[J].基因组学与应用生物学,2018,37(06):2383-2388.DOI:10.13417/j.gab.037.002383. (Li, W., Ran, H., & Chen, L. (2018). Molecular mechanism of zebrafish tail developmental malformation caused by low temperature stress. Genomics and Applied Biology, 37(6), 2383-2388.)

[24]储旭,周涛,李文豪,邢虎,陈良标.逆转座子LINE1在Hela细胞中的表达及转录组分析[J].大连海洋大学学报,2019,34(02):153-159.DOI:10.16535/j.cnki.dlhyxb.2019.02.001.

[25] 王小彤,李文豪,林枫,江守文,翟万营,吴智超,许强华. 独角雪冰鱼与其他三种南极鱼鳃组织的转录组差异分析[J]. 基因组学与应用生物学, 40(第 7-8 期合刊): 2574-2582.DOI: 10.13417 j.gab.040.002574. (Wang, X., Li, W., Lin, F., Jiang, S., Zhai, W., Wu, Z., & Xu, Q.(2021). Differential transcriptomic analysis of gill tissues between Chionodraco hamatus and other three antarctic fishes, Genomics and Applied Biology, 40(7-8 combined issue), 2574-2582.)

科教工作获奖情况

2020年, 海洋科学技术奖, 一等奖, 极地鱼类适应性进化机制研究, 第8完成人(8/15);

2021年, 入选江苏省双创团队.

联系方式

地址：海洋科技大楼10楼1004室

E-mail：wh-li@shou.edu.cn